The non-neoplastic endometrium adjacent to an endometrial adenocarcinoma was active in 43 of the 50 women; four were in the form of weakly proliferating glands and 39 in the form of a mixed inactive and weakly proliferative endometrium. When secretory phase endometrium was compared with control group secretory phase significant expression for PR was noted only in stroma. As a result of the anovulation, the corpus luteum does not develop, culminating in relative increase in estrogen levels and a relative decrease in progesterone levels. The events of the uterine cycle are regulated by the estrogen and progesterone produced by the ovaries during the ovarian cycle. 3. 2, 34 Endometrioid. 75% and endometrial carcinoma in 11. This diagnosis means that after examining your tissue sample under the microscope, your pathologist saw irregular and dilated endometrial glands in the proliferative phase (growing phase). In these areas the abnormal glands should be focal. For AH/EIN and normal control endometria, unstained 4 μm sections were cut from one representative tissue block for each case. Transition from disordered proliferative-phase endometrium (with subtle architectural alterations) to SH (with irregularly shaped, cystically dilated glands) may be seen. It is a mixture of cystically dilated, budding, and tubular glands in a. • 01-2021 Vaginal Ultrasound: Showed 3 fibroids, endometrium lining 8. ICD-10-CM Diagnosis Code H35. Diseases of the genitourinary system. Disclaimer: Information in questions answers, and. 62% of our cases with the highest incidence in 40-49 years age group. , 1998; Mettler et al. 4% cases. It results in an uncharacteristic thickening of the endometrium (lining of the uterus) The condition is also known as Endometrial Hyperplasia without Atypia. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. This diagnosis means that after examining your tissue sample under the microscope, your pathologist saw irregular and dilated endometrial glands in the proliferative phase (growing phase). Balls of cells? Blue - likely menstrual (stromal condensation). HYPERPLASIA) VERSUS DISORDERED PROLIFERATIVE ENDOMETRIUM •All part of a spectrum •Probably no (at most minimal) risk of progression •Don’t worry too much about distinction- not clinically important (don’t let clinicians tell you it is) •Tend to call disordered proliferative in perimenopausal years; tend to call hyperplasia In the human endometrium, estrogen drives tissue repair and epithelial proliferation during the proliferative phase and estrogen and progesterone promote thickening of the endometrium following ovulation. Most of the patients were in age group. Some consider disordered proliferative endometrium (DPE) a synonym for anovulatory endometrium. 6 Normal endometrium. 01 became effective on October 1, 2023. 7% patients, and proliferative phase pattern and. Menstrual cycles (amount of time between periods) that are shorter than 21 days. included disordered proliferative 26%, weakly proliferative 26%, inactive endometrium 26%, weakly secretory 07%, desynchronized endometrium 07% and simple hyperplasia 07%. Weakly proliferative endometrium suggests there has still been a little estrogen present to stimulate the endometrium, whether from your ovaries, adrenals, or from conversion in fat cells. , proliferative endometrium. Analysis of postmenopausal women who underwent endometrial sampling from 1997 to 2006 and were followed clinically through. Objective: We clarified cytology in metaplastic changes recognized in endometrial glandular and stromal breakdown (EGBD). Histopathology showed 16 cases of disordered proliferative endometrium, 12 cases of PEB, 13 cases of proliferative phases, five cases of secretory phase, threePerhaps a better usage refers to a proliferative phase endometrium that does not seem appropriate for any one time in the menstrual cycle but is not abnormal enough to be considered hyperplastic. IHC was done using syndecan-1. What is disorder proliferative endometrium? “Disordered proliferative endometrium” is a somewhat vague term that generally indicates the unusual growth of endometrial cells. Created for people with ongoing healthcare needs but benefits everyone. عند البحث عن معنى proliferative endometrium يجب العلم أنه ليس عرض من الأعراض أو حالة من الحالات الصحية، بل هو وصف للنشاط الصحي للخلايا الإنجابية في بطانة الرحم خاصة خلال الوقت من الدورة الشهرية الذي يتم فيه تحضير بطانة الرحم. 5%) endometrium (Fertil Steril 2021;115:1312, Int J Gynecol Pathol 2019;38:520) Focal stromal decidual-like changes Transitional cell metaplasia of ectocervical and transformation zone epithelium or cervical atrophy ( Obstet Gynecol 2021;138:51 )What does this mean? endometrium, biopsy: disordered proliferative endometrium with associated simple (cystic) hyperplasia. 5 mm up to 4. One in three patients with adenomyosis is asymptomatic, but the rest may present with heavy. Early diagnosis and treatment of EH (with or without atypia) can prevent progression to. 5 years; P<. 0001). Balls of cells? Blue - likely menstrual (stromal. 2 vs 64. Patients presenting with secretory phase were 32 (16%). The findings are a mixed-phase endometrium in which the proliferative component is disordered. 2 mm thick (mean, 2. Obstetrics and Gynecology 41 years experience. 5%) revealed secretory phase. Proliferative endometrium indicates the follicular phase; whereas, secretory endometrium indicates luteal phase. The most common histomorphological pattern was Endometrial Hyperplasia without atypia in 43. 1%) each. N85. 7. doi: 10. 6% of cases. disordered proliferative phase accounted for 14. In premenopausal women, proliferative endometrial changes result from ovarian estrogen production during what we call the proliferative phase of the menstrual cycle. Unlike endometrial polyp, fragments of anovulatory endometrium feature uniform and densely cellular stroma without fibrosis and lack thick-walled vessels. In the present study, cytohistological concordance was 100% for proliferative phase. Fifty endometrial biopsies were reviewed for presence of plasma cells on H and E and using IHC for syndecan- 1. Conclusion: FIGO/PALM-COEIN classification will be helpful in deciding treatment of AUB cases. be encountered in a disordered. read more. Study question: Does an early proliferative phase endometrial biopsy harvested during ovarian stimulation harbour information predictive of the outcome following fresh embryo transfer (ET) in that same cycle? Summary answer: Transcriptome analysis of the whole-tissue endometrium did not reveal significant differential gene expression. At ovulation, the oocyte is released from the dominant ovarian follicle. Proliferative-phase endometrial CD138 + cells may be an adverse indicator for pregnancy outcomes in fresh IVF/ICSI cycles, with a certain value in predicting non-pregnancy. …were disordered proliferative endometrium (15. Attention to the presence of artifacts (e. endometrial polyp 227 (9. 6. In cases of endometrial. 2 Microscopic. During the menstrual cycle, the endometrium cycles through a proliferative phase (growth phase) and secretory phase in response to hormones (estrogen and progesterone) made and released by the ovaries. Glands are straight and tubular without mitotic figures or pseudostratification. 1 Condensed Stromal Clusters (CSC) . Endometrial hyperplasia tends to occur in people who are transitioning to menopause or who have gone through menopause. Images Stromal staining of Ki67 was found to be more apparent in the secretory phase, however, it was found to be lower than that of the endometrial glands in the proliferative phase. During the proliferative phase of the menstrual cycle,. Out of 21 cases of endometrial hyperplasia simple hyperplasia constitute 17 cases and 4 cases of complex hyperplasia without atypia were observed [ Table/Fig-1 ]. Secretory phase endometrium was found in 13. 00 - other international versions of ICD-10 N85. 8 became effective on October 1, 2023. N85. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. AUB is frequently seen. . 41% greater in simple hyperplasia than in proliferative endometrium (p<0,05) (Figure 3), whereas Vv[stroma] was 37. 01 is a billable ICD code used to specify a diagnosis of benign endometrial hyperplasia. Under normal conditions the secretory phase is 14 days in length, and the endometrium moves through an orderly sequence of morphologic changes (Fig. 3 Menstrual endometrium. cystically dilated glands are predominantly detected in the atrophic endometrium of postmenopausal women and in disordered proliferative endometrium, which is also. Glands out of phase Irregular gland architecture. This study was performed to assess the long-term outcomes of postmenopausal women harboring PE on endometrial sampling. In this well-phenotyped population of healthy women, obesity was associated with significant endometrial proliferative phase proteomic differences affecting predominantly hormonal and immunological pathways. 4% cases. Common reasons for these procedures include: Abnormal (dysfunctional) uterine bleeding. Questions in the Menopause forum are answered by medical professionals and experts. 5%, Atrophic Endometrium in 13. The last menstrual period should be correlated with EMB results. Women with a proliferative endometrium were younger (61. Malignant lesion was not common and it comprised of only 1. H&E stain. Results: Out of 100 cases studied, 37% were found out to be secretory endometrium, 20% proliferative endometrium, 6% disordered endometrial glands, 3% simple hyperplasia without atypia, 5% complex. 6 Disordered proliferative endometrium; 7. Screening for endocervical or endometrial cancer. Cytological and histological examinations were conducted on 138 benign cases and 26 abnormal cases, including 24 cases with disordered proliferative phase (DOP) and 2 cases with simple endometrial. Women with a proliferative endometrium were younger (61. 85 FindingsDisordered proliferative endometrium is an exaggerated proliferative phase representing chronic anovulation in the perimenopausal years. 0; range, 1. However, there is little literature and no evidence-based treatments for a finding of proliferative endometrium without atypia on Pipelle endometrial biopsy in women presenting with PMB. The endometrium may develop endometrial hyperplasia (EH), which includes non-neoplastic entities (disordered proliferative endometrium, benign hyperplasia, simple and complex hyperplasias without atypia) characterized by a proliferation of endometrial glands, and endometrial intraepithelial neoplasms (EIN),. In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76. Should be easily regulated with hormones such as low dose b. 1. Bookshelf ID: NBK542229 PMID: 31194386. The stromal cells are arranged in a compact manner. Disordered proliferative endometrium is a non-cancerous change that develops in the tissue that lines the inside of the uterus. 01. Management of SIL Thomas C. Fibrosis of uterus NOS. Study design: This is a retrospective cohort study of 1808 women aged 55 years. The follicle then transforms into the corpus luteum, which secretes. 00 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Similar results of proliferative endometrium being the commonest were seen in Hoon CN et al,4 Muzaffar M et al,5 Maheshwari V et al,6 S. The latter may be focally crowded. Ralph Boling answered. . Family Medicine 49 years experience. Doctor of Medicine. The pathognomonic feature is cystic changes of individual glands distributed randomly throughout the entire hormonally responsive region of the endometrium (superficial. 56%). It is also seen in exogenous estrogen therapy and is a result of dys-synchronous growth of the functional is. 2 Secretory phase endometrium; 6. 4% of patients. During this phase, the endometrial glands grow and become tortuous because of the active. Nontumor: abnormal uterine bleeding adenomyosis / adenomyoma Arias-Stella reaction atrophy disordered proliferative endometrial metaplasia endometrial polyp endometritis exogenous hormones histology of specimens from gender affirming surgery in individuals assigned female at birth. 63 Products of Conception 1 0. Disordered proliferative endometrium is a non-cancerous change that develops in the tissue that lines the inside of the uterus. It generally occurs due to long. 0 - Endometrial hyperplasia. 2%), disordered endometrium (19. We performed an analysis of the development of proliferative phase endometrium in 246 cycles. Symptoms?: I assume this was a result of an endometrial biopsy done for heavy or irregular bleeding. This phase is variable in length and oestradiol is the dominant hormone. 6. What. During the menstrual cycle, the endometrium cycles through a proliferative phase (growth phase) and secretory phase in response to hormones (estrogen and progesterone) made and released by the ovaries. 8 is applicable to female patients. 2023 Feb 1;141 (2):265-267. One pattern had moderately dilated glands, much as would be encountered in a disordered proliferative endometrium (a),. 0001). Disordered proliferative endometrium is common in the perimenopausal years because of anovulatory cycles. proliferative endometrium, followed by disordered proliferation comprising 58 (29%) patients [Figure 2]. N85. Your doctor could order an endometrial biopsy for several reasons: Abnormal bleeding from the vagina: In post-menopausal women, this would mean any bleeding at all. The distinction can be difficult sometimes, in which case I convey the uncertainty as: "Anovulatory (disordered proliferative) endometrium. 9 Ablated endometrium;weakly proliferative endometrium with occasional mitotic figures and a thin functionalis layer. 1% of cases and these findings were consistent with findings in study done by Jetley et al. In a series of 15 cases, endometrial ASCs were found in the context of endometrial polyps except for two cases associated with proliferative phase and disordered proliferative endometrium [10]. Obstetrics and Gynecology 20 years experience. The endometrium must be destroyed or resected to the level of the basalis ,… This technique may be performed during either the proliferative or secretory phase of the cycle. During this phase, the endometrial glands grow and become. Proliferative phase 54 34. 2 Proliferative Endometrium Proliferative endometrium comprises of nonbranching, nonbudding, similarly shaped glands evenly distributed throughout a cellular spindly stroma. 1%), carcinoma (4. Cystically dilated glands with outpouchings. Learn how we can help. The anovulatory cycle is the cause for bleeding in the proliferative phase, and bleeding in the secretory phase is. breakdown. Common reasons for these procedures include: Abnormal (dysfunctional) uterine bleeding. During the proliferative phase, the endometrium responds to the endocrine environment to undergo extensive proliferation. Telescoping of glands (right panel) as well as artifactual juxtaposition of glands in a fragmented specimen can create an appearance of glandular overcrowding and mimic AEH/EIN. 63The distinction between SH and disordered proliferative endometrium is often difficult, since one may arise from the other, and mixed lesions are frequent. Endometrium with hormonal changes. Menopause Forum. Diseases of the genitourinary system. IHC was done using syndecan-1. 1% cases in our study as compared to 32. Of the 142 specimens, 59 (41. N85. indistinguishable from a disordered proliferative, or anovulatory, endometrium. Dr. . Based on an average 28-day menstrual cycle, proliferative endometrial changes may be divided into early (days 4–7), mid (days 8–10), and late (days 11–13) intervals. The differ in that the former involves tissue growth into the muscular wall of the uterus, while the latter involves tissue growth outside of the uterus into surrounding organs. Of 25 women with endometrial hyperplasia, simple hyperplasia without atypia, complex hyperplasia without atypia and complex. Thickened: lining of your uterus: may be a hormone effect and responsive to oral contraceptives. 2%), followed by secretory endometrium (34%) and endometrial hyperplasia (16%). Read More. These phases are illustrated in Figure [Math Processing Error] 22. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. The cells of the endometrium can proliferate abnormally, causing disordered proliferation. 64 Disordered proliferative phase 20 12. The endometrium measures less than 0. Endometrial hyperplasia is a disordered proliferation of endometrial glands. Endometrial hyperplasia without atypia (as in the 2020 WHO classification) is defined as the proliferation of endometrial glands of irregular size and shape without significant cytological atypia. 6% smaller. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk. simple proliferative no nuclear atypia, endometrial Disordered focally dilated & can be thought +/-evidence of hyperplasia, proliferative irregular glands of a waffle shedding (stromal proliferative endometrium (usu. 4% cases. If the biopsy was done in the first half of the cycle, the endometrium is expected to be in proliferative phase. Similar to nonatypical hyperplasia, benign endometrium during the proliferative and secretory phases can mimic AEH/EIN. DPE has prominent gland dilation (reminiscent of simple endometrial hyperplasia) and may not have shedding. Henry Dorn answered. 0: Endometrial polyp: 3:. the luteal phase of the menstrual cycle that opposes. The first phase of the menstrual cycle is the follicular or proliferative phase. Most patients tend to display a multiplicity of findings. Ed Friedlander and 4 doctors agree. Not having a period (pre-menopause) During the proliferative phase, the endometrium responds to the endocrine environment to undergo extensive proliferation. hyperplasia and the proliferative endometrium except for Sv[outer] and Lv[gland]. N85. Normal cyclical endometrium was seen in 165 (40. 6 kg/m 2; P<. N85. . Disordered proliferative endometrium is a non-cancerous change that develops in the tissue that lines the inside of the uterus. 86 Another common term is disordered proliferative endometrium. Obstetrics and Gynecology 27 years experience. Where there were discrepancies between assignment as disordered proliferative endometrium or HwA, cases were upgraded into the HwA category. In menopausal women not using. 6. Bleeding in the proliferative phase may be due to anovulatory cycle in such cases shows progressive. Pregnancy outcome was poor when CD138 + cells/HPF ≥ 2 in the endometrium and may worsen with the increase in CD138 + cells. My endometrial biopsy says weakly proliferative endometrium with focal eosinophilic changes. Disordered or dyssynchronous endometrium suggests ovulatory dysfunction. The pathognomonic feature is cystic changes of individual glands distributed randomly throughout the entire hormonally responsive region of the endometrium (superficial functionalis. Screening for endocervical or endometrial cancer. Objective: This study aimed to report on the long. As a result, the top layers of the thickened lining of the. 17 Secretory phase 50 31. Monoclonal growth and mutation of tumor-suppressor genes are measurable features of the premalignant phase of endometrial tumorigenesis that can be directly ascertained in paraffin-embedded tissues and correlated with histology on a case-by-case basis. The most common is endometrial hyperplasia, where too much estrogen and too little. 7% cases comparing favorably with 14% and 22% in other studies. " I told him that the nurse midwife had reported there were concerns w/ the pathology report, and she told me she couldn't tell. ICD-10-CM Coding Rules. Disordered proliferative pattern resembles a simple hyperplasia, but the process is focal rather than diffuse. Disordered proliferative phase endometrium what is the medicine for this case? Dr. A proliferative endometrium is a normal part of healthy uterine function when it occurs during the first half of the menstrual cycle. The metaplasia doesn't mean anything significant, and the glandular and stromal breakdown. The disordered proliferative endometrium resembles normal proliferative. What is the treatment for disordered proliferative endometrium? The most common treatment is progestin. . Proliferative endometrium is a term that refers to healthy reproductive cell activity. N80-N98 - Noninflammatory disorders of female genital tract. Created for people with ongoing healthcare needs but benefits everyone. Normal. 13, 14 However, it maintains high T 2 WI signal. 6. Your endometrial biopsy results is completely benign. In other words, estrogen stimulates the endometrium to grow and thicken. The other diagnoses, which accounted for the rest of the functional causes of atypical uterine bleeding, were disordered proliferative endometrium 15 cases (6. Streaming effects seen in stromal cells is a significant finding in smears from. Metaplasia is defined as a change of one cell type to another cell type. Benign endometrial polyp - has thick-walled blood vessels; simple endometrial hyperplasia should not be diagnosed in a polyp. A note from Cleveland Clinic. However, there is little literature and no evidence-based treatments for a finding of proliferative endometrium without atypia on Pipelle endometrial biopsy in women. , 7%. If this normal process ever leads to the unusual growth of endometrial cells, it’s referred to as disordered. Contact your doctor if you experience: Menstrual bleeding that is heavier or longer-lasting than usual. At this time, ultrasound exhibits a high echo. 4%), and endometrial cancer in 2 women (1. 7 Endometrium with changes due to exogenous hormones; 7. Post-menopausal bleeding (PMB) is usually caused by several endometrial conditions (hyperplasia and carcinoma) for which there are evidence-based treatments. 06 Hyperplasia 6 3. Metaplasia is defined as a change of one cell type to another cell type. 5 mm in thickness, and the surface and glands are lined by a low columnar to cuboidal epithelium devoid of either proliferative or secretory activity, which. The endometrium is generally assessed by ultrasound or MRI examination. 00. 16 Miranda et al. Endometrial hyperplasia (EH) comprises a spectrum of changes in the endometrium ranging from a slightly disordered pattern that exaggerates the alterations seen in the late proliferative phase of the menstrual cycle to irregular, hyperchromatic lesions that are similar to endometrioid adenocarcinoma. Occasionally in the latter situation, when the proliferative phase is prolonged, there may be sufficient residual oestrogen secretion to give rise to a ‘disordered proliferative endometrium’, characterised by mild glandular architectural. The proliferative phase has a variable length from 10 to 20 days, with an ideal duration of 14 days. 41 as secretory phase, 15 as disordered proliferative endometrium, 6 as. 4. Proliferative endometrium has three phases: early, mid, and late . Disordered proliferative endometrium is a condition where the endometrial cells are prepared for attachment of a fertilized egg, but the growth is disordered. 3. Disordered proliferative phase endometrium what is the medicine for this case? Dr. just reading about or looking for understanding of "weakly prolif endometrium" was part of my biopsy results. 5%); other causes include benign endometrial polyp (11. Proliferative phase endometrium: 42%: Simple hyperplasia: 26%: Simple hyperplasia with atypia: 23%: Complex hyperplasia: 16%: Complex hyperplasia with atypia: 42%: WHO system of 1994 - detail articles. A nested case-control study of EH progression, using extensive histopathology reports, concluded that AH was 14 times more likely to progress to endometrial carcinoma as compared to the women that presented with disordered proliferative endometrium without hyperplasia. Disordered proliferative phase was the commonest (16%) functional cause of abnormal bleeding and diagnosis. 5% of the cases, with the highest incidence in the age. 5 years; P<. At the end of this stage, around the 14th day, the. When the follicular phase begins, levels of estrogen and progesterone are low. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. 00 may differ. Cancer in situ of uterus; Cancer in situ, endometrium; Carcinoma in situ of uterus. - Negative for polyp, hyperplasia, atypia or malignancy. The pathognomonic feature of persistent estrogen stimulation is architectural changes of individual glands distributed randomly throughout the entire. Glands/cells identical to proliferative endometrium Abundant stroma Gland:Stroma ratio often 1:1, if becomes >2:1, then consider hyperplasia (see endometrial tumor notes) Often coinciding breakdown Endometrial glands and stroma outside of their usual endometrial cavity location→cause dysmenorrhea and/or menorrhagia AdenomyosisSPE - eosinophilic cytoplasm. 00. Early proliferative endometrium (days 3–6). The uterus is the fusion product of the embryologic paramesonephric (müllerian) ducts. Page # 5 Persistent. Also part of the differential diagnosis of simple hyperplasia are normal cycling endometrium, disordered proliferative phase, various compression artifacts, and. The occurrence of endometrial malignancy was remarkable, i. 01 - Benign endometrial hyperplasia. Polyp was present in 7. Normal proliferative phase endometrial smears show large tissue fragments with tubular lumen with in it. During secretory phase (Days 15–28), the endometrium measures 16–18 mm and is more echogenic . 2; median, 2. Female Genital Pathology. Epub 2023 Jan 4. The ratio of glands to stroma increases compared to the normal proliferative phase endometrium, exceeding the ratio of 3:1 in hyperplasia. More African American women had a proliferative. More African American women had a. Malignant lesion was not common and it comprised of only 1. Report attached. The most common cause of uterine bleeding was found to be proliferative phase endometrium; that were 649 cases (56. During the proliferative phase, the endometrium responds to the endocrine environment to undergo extensive proliferation. Some consider disordered proliferative endometrium (DPE) a synonym for anovulatory endometrium. Proliferative endometrium was seen in 14. No evidence of endometrium or malignancy. 9. In a study of endometrial pathology in abnormal uterine bleeding it has been found that the commonest pathology causing abnormal uterine bleeding (AUB) is disordered proliferative pattern (20. Disordered proliferative endometrium is an exaggeration of the normal proliferative phase; and, as such, much of the tissue is similar to that seen in normal proliferative endometrium. Conclusion: Atypical uterine bleeding in perimenopausal women is most commonly dysfunctional in origin. 0–3. Instead, DPE is characterized by irregularly shaped, cystically dilated glands producing a disordered arrangement. 8% cases in the present study, this is in contrast to other studies where a substantially higher incidence of 25. 22 reported that the expression of Ki-67 were significantly higher in the polyp samples from tamoxifen-treated women compared with. Cytoplasmic vacuoles become supranuclear and secretions are seen within glandular lumina (Fig. Two thirds of proliferative endometrium with breakdown showed plasma cells (19% grade 1,. 8%), luteal phase defects 3 cases (1. In a study of 111 premenopausal women with abnormal uterine. Physician. 3%). The first phase of the menstrual cycle is the follicular or proliferative phase. In disordered proliferative endometrium, the. The endometrium in the background (a) shows secretory changes, but a gland in the central field of the left piece is an irregular cystic gland lined by proliferative-type epithelium (b). 2 Secretory phase endometrium; 6. 0 mm in thickness, so by the late proliferative phase, a biopsy obtains a moderate amount of tissue. There are various references to the histological features of DUB [1,2,3,4]. See also: endometriumEndometrial macrophage populations are reported to be relatively stable across the menstrual cycle, with numbers increasing only in the late secretory/menstrual phase and early proliferative phase of the menstrual cycle . Dr. Benign endometrial polyp - has thick-walled blood vessels; simple endometrial hyperplasia should not be diagnosed in a polyp. Proliferative endometrium on the other hand was seen in only 6. Proliferative phase (days 6 - 14): Stratum functionalis is regenerated by cells from stratum basalisDisordered proliferative phase. Dr. Kayastha7 and other studies. Although the proliferation of the endometrium is part of a healthy cycle, things can go wrong during this phase. Henry Dorn answered. read more. Adenomyosis and endometriosis are chronic conditions that affect the endometrium, the tissue lining of the uterus. Proliferative phase (days 6 - 14): Stratum functionalis is regenerated by cells from stratum basalis Disordered proliferative phase. [1] Libre Pathology separates the two. Histopathological analysis of endometrial curettings showed Proliferative phase in 35%, disordered proliferative phase in 17. 2, 34 Endometrioid. Biopsy proliferative phase endometrium with disorder features and focal stromal breakdown.